TargetMol

INDY

Product Code:
 
TAR-T15579
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15579-5mg5mg£115.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15579-1mL1 mL * 10 mM (in DMSO)£118.00
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Quantity:
TAR-T15579-10mg10mg£129.00
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Quantity:
TAR-T15579-25mg25mg£161.00
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Quantity:
TAR-T15579-50mg50mg£200.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
CAS:
1169755-45-6
Formula:
C12H13NO2S
Molecular Weight:
235.3
Pathway:
Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint
Purity:
0.9815
SMILES:
CCN1C(Sc2ccc(O)cc12)=CC(C)=O
Target:
DYRK

References

1. Ogawa Y, et al. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat Commun. 2010 Oct 5;1:86. 2. Pozo N, et al. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastomagrowth. J Clin Invest. 2013 Jun;123(6):2475-87.