TargetMol

IDH889

Product Code:
 
TAR-T15551
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15551-1mg1mg£163.00
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TAR-T15551-5mg5mg£269.00
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TAR-T15551-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T15551-10mg10mg£402.00
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TAR-T15551-25mg25mg£625.00
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TAR-T15551-50mg50mg£860.00
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Further Information

Bioactivity:
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
CAS:
1429179-07-6
Formula:
C23H25FN6O2
Molecular Weight:
436.491
Pathway:
Metabolism
Purity:
0.98
SMILES:
CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cn2)-c2ccc(F)c(C)c2)n1
Target:
Dehydrogenase

References

1. Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.