TargetMol

Inavolisib

Product Code:
 
TAR-T15375
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15375-1mg1mg£234.00
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TAR-T15375-5mg5mg£403.00
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TAR-T15375-1mL1 mL * 10 mM (in DMSO)£412.00
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TAR-T15375-10mg10mg£613.00
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TAR-T15375-25mg25mg£852.00
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TAR-T15375-50mg50mg£1,219.00
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Quantity:
TAR-T15375-100mg100mg£1,621.00
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TAR-T15375-200mg200mg£2,151.00
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TAR-T15375-500mg500mg£3,179.00
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Further Information

Bioactivity:
GDC-0077 is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). GDC-0077 is more selective for mutant versus wild-type PI3Kα. GDC-0077 exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
CAS:
2060571-02-8
Formula:
C18H19F2N5O4
Molecular Weight:
407.378
Pathway:
PI3K/Akt/mTOR signaling; Apoptosis
Purity:
0.9851
SMILES:
C[C@H](Nc1ccc2-c3nc(cn3CCOc2c1)N1[C@@H](COC1=O)C(F)F)C(N)=O
Target:
Apoptosis; PI3K

References

1. R Hong, Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies. 2017 San Antonio Breast Cancer Symposium.