TargetMol

Flindokalner

Product Code:
 
TAR-T15286
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15286-1mg1mg£114.00
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TAR-T15286-5mg5mg£173.00
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TAR-T15286-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T15286-10mg10mg£222.00
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TAR-T15286-25mg25mg£389.00
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TAR-T15286-50mg50mg£546.00
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TAR-T15286-100mg100mg£749.00
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Further Information

Bioactivity:
Flindokalner is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner displays a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM) and acts as a negative modulator of GABAA receptors and it also shows anxiolytic efficacy in vivo.
CAS:
187523-35-9
Formula:
C16H10ClF4NO2
Molecular Weight:
359.7
Pathway:
Membrane transporter/Ion channel
Purity:
0.9925
SMILES:
COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Target:
Potassium Channel

References

1. Korsgaard MP, et al. Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7channels. J Pharmacol Exp Ther. 2005 Jul;314(1):282-92. 2. Son YK, et al. The inhibitory effect of Ca2+-activated K+ channel activator, BMS on L-type Ca2+ channels in rat ventricular myocytes. Life Sci. 2011 Aug 29;89(9-10):331-6.