TargetMol

CMPD1

Product Code:
 
TAR-T14988
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14988-1mg1mg£106.00
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TAR-T14988-2mg2mg£120.00
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TAR-T14988-5mg5mg£148.00
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TAR-T14988-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T14988-10mg10mg£201.00
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TAR-T14988-25mg25mg£327.00
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TAR-T14988-50mg50mg£530.00
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TAR-T14988-100mg100mg£731.00
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TAR-T14988-500mg500mg£1,428.00
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Further Information

Bioactivity:
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330?nM).
CAS:
41179-33-3
Formula:
C22H20FNO2
Molecular Weight:
349.405
Pathway:
MAPK
Purity:
0.9967
SMILES:
Oc1ccc(NC(=O)CCCc2ccc(cc2)-c2ccccc2F)cc1
Target:
MAPK

References

1. Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028. 2. Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71. 3. Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.