TargetMol

BNC105

Product Code:
 
TAR-T14694
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14694-1mg1mg£173.00
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TAR-T14694-5mg5mg£289.00
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TAR-T14694-1mL1 mL * 10 mM (in DMSO)£310.00
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TAR-T14694-10mg10mg£389.00
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TAR-T14694-25mg25mg£594.00
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TAR-T14694-50mg50mg£804.00
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TAR-T14694-100mg100mg£1,058.00
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Further Information

Bioactivity:
BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.
CAS:
945771-74-4
Formula:
C20H20O7
Molecular Weight:
372.373
Pathway:
Cytoskeletal Signaling
Purity:
0.9657
SMILES:
COc1ccc2c(C(=O)c3cc(OC)c(OC)c(OC)c3)c(C)oc2c1O
Target:
Microtubule Associated

References

1. Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. 2. Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. 3. Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60.