TargetMol

AS1949490

Product Code:
 
TAR-T14327
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14327-1mg1mg£98.00
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TAR-T14327-2mg2mg£109.00
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TAR-T14327-5mg5mg£135.00
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TAR-T14327-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T14327-10mg10mg£173.00
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TAR-T14327-25mg25mg£282.00
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TAR-T14327-50mg50mg£410.00
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TAR-T14327-100mg100mg£565.00
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Further Information

Bioactivity:
AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5? phosphatase 2) inhibitor, with an IC50 of 620 nM.
CAS:
1203680-76-5
Formula:
C20H18ClNO2S
Molecular Weight:
371.88
Pathway:
Metabolism
Purity:
0.9916
SMILES:
C[C@H](NC(=O)c1sccc1OCc1ccc(Cl)cc1)c1ccccc1
Target:
Phosphatase

References

1. Suwa A, et al. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIPBr J Pharmacol. 2009 Oct;158(3):879-87. 2. Suwa A, et al. Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur J Pharmacol. 2010 Sep 10;642(1-3):177-82.