TargetMol

AMG 579

Product Code:
 
TAR-T14217
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14217-1mg1mg£118.00
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TAR-T14217-2mg2mg£140.00
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TAR-T14217-5mg5mg£185.00
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TAR-T14217-1mL1 mL * 10 mM (in DMSO)£197.00
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TAR-T14217-10mg10mg£252.00
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TAR-T14217-25mg25mg£405.00
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TAR-T14217-50mg50mg£568.00
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Further Information

Bioactivity:
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
CAS:
1227067-61-9
Formula:
C25H23N5O3
Molecular Weight:
441.48
Pathway:
Metabolism
Purity:
0.9935
SMILES:
O=C(C1=CC=C(OC2=NC=CN=C2C3CCN(C(=O)C)CC3)C=C1)C4=NC=5C=CC=CC5N4
Target:
PDE

References

1. Hu E,et al. Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). J Med Chem. 2014 Aug 14;57(15):6632-41.