TargetMol

PI3K/mTOR Inhibitor-2

Product Code:
 
TAR-T12459
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12459-1mg1mg£142.00
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TAR-T12459-5mg5mg£269.00
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TAR-T12459-1mL1 mL * 10 mM (in DMSO)£278.00
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TAR-T12459-10mg10mg£389.00
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TAR-T12459-25mg25mg£605.00
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TAR-T12459-50mg50mg£831.00
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TAR-T12459-100mg100mg£1,099.00
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TAR-T12459-500mg500mg£2,135.00
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Further Information

Bioactivity:
PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.
CAS:
1848242-58-9
Formula:
C20H13ClF2N4O4S
Molecular Weight:
478.85
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(Cl)c(=O)n2c1
Target:
PI3K; mTOR

References

1. Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.