TargetMol

PF-06821497

Product Code:
 
TAR-T12430
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12430-1mg1mg£227.00
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Quantity:
TAR-T12430-5mg5mg£422.00
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Quantity:
TAR-T12430-1mL1 mL * 10 mM (in DMSO)£487.00
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TAR-T12430-10mg10mg£589.00
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TAR-T12430-25mg25mg£863.00
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Quantity:
TAR-T12430-50mg50mg£1,179.00
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Quantity:
TAR-T12430-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.
CAS:
1844849-10-0
Formula:
C22H24Cl2N2O5
Molecular Weight:
467.34
Pathway:
Chromatin/Epigenetic
Purity:
0.9788
SMILES:
CO[C@H](C1COC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
Target:
Histone Methyltransferase

References

1. Kung PP, et al. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2018 Feb 8;61(3):650-665.