TargetMol

Ned 19

Product Code:
 
TAR-T12205
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12205-1mg1mg£189.00
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TAR-T12205-5mg5mg£340.00
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TAR-T12205-1mL1 mL * 10 mM (in DMSO)£409.00
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TAR-T12205-10mg10mg£470.00
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TAR-T12205-25mg25mg£707.00
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TAR-T12205-50mg50mg£978.00
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Quantity:
TAR-T12205-100mg100mg£1,291.00
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Quantity:
TAR-T12205-500mg500mg£2,456.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
CAS:
874374-25-1
Formula:
C30H31FN4O3
Molecular Weight:
514.601
Pathway:
Metabolism; Membrane transporter/Ion channel
Purity:
0.9855
SMILES:
COc1ccc(cc1CN1CCN(CC1)c1ccccc1F)C1NC(Cc2c1[nH]c1ccccc21)C(O)=O
Target:
Calcium Channel

References

1. Rosen D, et al. Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonistNed-19 indicate two binding sites on the NAADP receptor. J Biol Chem. 2009 Dec 11;284(50):34930-4. 2. Annarita Favia, et al. NAADP-Dependent Ca2+ Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis. Sci Rep. 2016; 6: 18925.