TargetMol

NB-360

Product Code:
 
TAR-T12188
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12188-1mg1mg£221.00
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TAR-T12188-5mg5mg£389.00
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TAR-T12188-1mL1 mL * 10 mM (in DMSO)£422.00
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TAR-T12188-10mg10mg£544.00
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TAR-T12188-25mg25mg£830.00
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TAR-T12188-50mg50mg£1,099.00
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TAR-T12188-100mg100mg£1,460.00
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TAR-T12188-500mg500mg£2,850.00
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Further Information

Bioactivity:
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
CAS:
1262857-73-7
Formula:
C21H19F4N5O2
Molecular Weight:
449.41
Pathway:
Neuroscience
Purity:
0.9925
SMILES:
Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N
Target:
BACE

References

1. Neumann U, et al. Mol Neurodegener. 2015 Sep 3;10:44. doi: 10.1186/s13024-015-0033-8. 2. Neumann U, et al. The ?-secretase (BACE) inhibitor NB-360 in preclinical models: From amyloid-? reduction to downstream disease-relevant effects. Br J Pharmacol. 2019 Sep;176(18):3435-3446.