TargetMol

IACS-9571 Hydrochloride (1800477-30-8 free base)

Product Code:
 
TAR-T11597L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11597L-200mg200mgEnquire
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TAR-T11597L-500mg500mgEnquire
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TAR-T11597L-1mg1mg£157.00
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TAR-T11597L-5mg5mg£320.00
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TAR-T11597L-1mL1 mL * 10 mM (in DMSO)£442.00
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TAR-T11597L-10mg10mg£532.00
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TAR-T11597L-50mg50mg£1,662.00
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TAR-T11597L-100mg100mg£2,404.00
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Further Information

Bioactivity:
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
CAS:
T11597L
Formula:
C32H43ClN4O8S
Molecular Weight:
679.22
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
[H]Cl.O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC(OCCC)=CC(OCCCCN(C)C)=C3)C=C(N4C)C(N(C)C4=O)=C2)=O
Target:
Epigenetic Reader Domain

References

1. Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54.