TargetMol

GNE-1858

Product Code:
 
TAR-T11438
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11438-1mg1mg£211.00
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TAR-T11438-5mg5mg£369.00
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TAR-T11438-1mL1 mL * 10 mM (in DMSO)£389.00
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TAR-T11438-10mg10mg£517.00
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TAR-T11438-25mg25mg£790.00
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TAR-T11438-50mg50mg£1,050.00
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TAR-T11438-100mg100mg£1,396.00
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TAR-T11438-500mg500mg£2,713.00
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Further Information

Bioactivity:
GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).
CAS:
2680616-96-8
Formula:
C21H26F2N8
Molecular Weight:
428.492
Pathway:
; MAPK
Purity:
0.987
SMILES:
CC(C)n1ncc2cnc(Nc3cc(nc(n3)N3CCC(F)(F)C3)C3CCNC3)cc12
Target:
MAPK

References

1. Wu P, et al. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure. 2019 Jan 2;27(1):125-133.e4.