TargetMol

GCN2-IN-6

Product Code:
 
TAR-T11374
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11374-5mg5mg£304.00
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TAR-T11374-50mg50mg£1,163.00
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TAR-T11374-100mg100mg£1,934.00
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This product comes from: United States.
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Further Information

Bioactivity:
GCN2-IN-6 is a potent and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50: 1.8 nM) and cellular assays (IC50: 9.3 nM).?GCN2-IN-6 is also an eIF2α kinase PERK inhibitor with IC50s of 0.26 nM in enzymatic assay and 230 nM in cells respectively.
CAS:
2183470-09-7
Formula:
C19H12Cl2F2N4O3S
Molecular Weight:
485.29
Pathway:
Apoptosis;
Purity:
0.98
SMILES:
Nc1ncc(cn1)C#Cc1c(F)ccc(NS(=O)(=O)c2cc(Cl)cc(CO)c2Cl)c1F
Target:
PERK

References

1. Fujimoto J, et al. Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503.