TargetMol

Darbufelone

Product Code:
 
TAR-T10960
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10960-1mg1mg£120.00
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TAR-T10960-5mg5mg£177.00
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TAR-T10960-1mL1 mL * 10 mM (in DMSO)£222.00
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TAR-T10960-10mg10mg£250.00
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TAR-T10960-25mg25mg£464.00
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TAR-T10960-50mg50mg£645.00
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TAR-T10960-100mg100mg£863.00
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TAR-T10960-500mg500mg£1,661.00
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This product comes from: United States.
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Further Information

Bioactivity:
Darbufelone is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.
CAS:
139226-28-1
Formula:
C18H24N2O2S
Molecular Weight:
332.46
Pathway:
Immunology/Inflammation; GPCR/G Protein
Purity:
0.98
SMILES:
CC(C)(C)c1cc(C=C2/SC(N)=NC2=O)cc(c1O)C(C)(C)C
Target:
Prostaglandin Receptor; LTR

References

1. Johnson AR, et al. Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 2001 Jun 26;40(25):7736-45. 2. Ye X, et al. Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo. Cancer Chemother Pharmacol. 2010 Jul;66(2):277-85.