TargetMol

BI-749327

Product Code:
 
TAR-T10537
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10537-1mg1mg£179.00
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TAR-T10537-5mg5mg£303.00
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TAR-T10537-1mL1 mL * 10 mM (in DMSO)£325.00
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TAR-T10537-10mg10mg£436.00
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TAR-T10537-25mg25mg£675.00
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TAR-T10537-50mg50mg£922.00
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Quantity:
TAR-T10537-100mg100mg£1,219.00
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This product comes from: United States.
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Further Information

Bioactivity:
BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
CAS:
2361241-23-6
Formula:
C23H21F3N4O2
Molecular Weight:
442.442
Pathway:
Membrane transporter/Ion channel
Purity:
0.9974
SMILES:
Nc1ccc(nn1)C1CCN(CC1)C(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1
Target:
TRP/TRPV Channel

References

1. Lin B L, et al. In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161.