TargetMol

Antisauvagine-30 TFA (220673-95-0 free base)

Product Code:
 
TAR-T10338
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10338-1mg1mg£497.00
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Quantity:
TAR-T10338-5mg5mg£1,344.00
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Further Information

Bioactivity:
Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.
CAS:
T10338
Formula:
C163H275N48F3O49S
Molecular Weight:
3764.28
Purity:
0.98
SMILES:
OC(C(F)(F)F)=O.[(D-Phe)-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2]

References

1. Brauns O, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41(4):507-16. 2. Sananbenesi F, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci. 2003 Dec 10;23(36):11436-43. 3. Radulovic J, et al. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J Neurosci. 1999 Jun 15;19(12):5016-25. 4. Klaus Eckart, et al. Action of CRF and its analogs. Current Medicinal Chemistry, 1999, 6, 1035-1053.