TargetMol

7 α-Hydroxy-4-cholesten-3-one

Product Code:
 
TAR-T10196
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10196-5mg5mg£662.00
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TAR-T10196-50mg50mg£1,661.00
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Quantity:
TAR-T10196-100mg100mg£2,079.00
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Further Information

Bioactivity:
7α-Hydroxy-4-cholesten-3-one is an intermediate in the synthesis of bile acids from cholesterol. It is a PXR agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss and other diseases associated with defective bile acid biosynthesis.It is the physiological substrate for CYP8B1.
CAS:
3862-25-7
Formula:
C27H44O2
Molecular Weight:
400.647
Purity:
0.98
SMILES:
[H][C@@]12CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@H](O)CC2=CC(=O)CC[C@]12C

References

1. Offei SD, et al. Chemical synthesis of 7?-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption. Steroids. 2019 Nov;151:108449. 2. G?lman C, et al. Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. Gastroenterology. 2005 Nov;129(5):1445-53.