NFAT2 Antibody / NFATC1

Western blot: 0.5-1ug/ml,Direct ELISA: 0.1-0.5ug/ml

Optimal dilution of the NFAT2 antibody should be determined by the researcher.

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

NFATC1 (Nuclear factor of activated T-cells, cytoplasmic 1), also known as NFATC or NFAT2, is a protein that in humans is encoded by the NFATC1 gene. And it is also a component of the nuclear factor of activated T cells DNA-binding transcription complex. The NFATC1 gene is mapped on 18q23. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. NFATC1 was not detected in brain, liver, or kidney. NFATC1 is an inducible nuclear component which functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. The solution structure of the binary complex formed between the core DNA-binding domain of human NFATC1 and the 12-bp oligonucleotide duplex containing the ARRE2 DNA site from the IL2 promoter. Nfatc1 was expressed exclusively in mouse hair follicle stem cells, and using gain- and loss-of-function approaches, and Nfatc1 inhibited stem cell activation.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

A human recombinant protein (amino acids F374-E710) was used as the immunogen for the NFAT2 antibody.

This NFAT2 antibody is available for research use only.

Affinity purified

Human

O95644