VDR Antibody / Vitamin D Receptor

Western blot: 1:500-1:2000

Optimal dilution of the Vitamin D Receptor antibody should be determined by the researcher.

The VDR gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [RefSeq]

Purified

Antibody in PBS with 0.02% sodium azide and 50% glycerol

A synthetic peptide specific to human Vitamin D Receptor / VDR was used as the immunogen for the Vitamin D Receptor antibody.

This Vitamin D Receptor antibody is available for research use only.

Affinity purified

Human, Mouse

P11473