NSJ Bioreagents

HLA-B Antibody (MHC Class I)

Product Code:
 
NSJ-V8848
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
SPM420
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunofluorescence (IF)
Storage:
 
Aliquot the HLA-B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
NSJ-V8848-20UG20ug£264.00
Quantity:
NSJ-V8848-100UG100ug£534.00
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Application Details :
Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml
Application Note:
Optimal dilution of the HLA-B antibody should be determined by the researcher.
Description:
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
Normal human peripheral blood lymphocytes were used as the immunogen for the HLA-B antibody.
Limitation:
This HLA-B antibody is available for research use only.
Localization:
Cell Surface
Purity:
Protein A/G affinity
Species Reactivity :
Human
Uniprot #:
P01889