NSJ Bioreagents

Irf3 Antibody

Product Code:
 
NSJ-F47744
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot the Irf3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
1 / 1
Irf3 antibody western blot analysis in mouse liver tissue lysate. Predicted molecular weight ~47KD
❮❯

Irf3 antibody western blot analysis in mouse liver tissue lysate. Predicted molecular weight ~47KD

No additional charges, what you see is what you pay! *

CodeSizePrice
NSJ-F47744-0.08ML0.08 ml£260.00
Quantity:
NSJ-F47744-0.4ML0.4 ml£502.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Application Details :
Western blot: 1:1000
Application Note:
Titration of the Irf3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 46-72 from the mouse protein was used as the immunogen for this Irf3 antibody.
Limitation:
This Irf3 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Mouse
Species Reactivity (Predicted):
Bovine, Pig
Uniprot #:
P70671