NSJ Bioreagents

RIG-I Antibody

Product Code:
 
NSJ-F46991
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot the RIG-I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of RIG-I antibody 24-hour post infection of primary murine microglia cells (2x10e6) untreated (0) or exposed to vesicular stomatitis virus at a range of viral particle/cell ratios. Predicted molecular weight ~106 kDa
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Western blot testing of RIG-I antibody 24-hour post infection of primary murine microglia cells (2x10e6) untreated (0) or exposed to vesicular stomatitis virus at a range of viral particle/cell ratios. Predicted molecular weight ~106 kDa

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CodeSizePrice
NSJ-F46991-0.08ML0.08 ml£260.00
Quantity:
NSJ-F46991-0.4ML0.4 ml£502.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details :
Western blot: 1:1000
Application Note:
Titration of the RIG-I antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, RIG-I triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 894-925 from the human protein was used as the immunogen for this RIG-I antibody.
Limitation:
This RIG-I antibody is available for research use only.
Purity:
Purified
Species Reactivity :
Human, Mouse
Uniprot #:
O95786