BMPR1B Antibody

Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 134-162 from the human protein was used as the immunogen for this BMPR1B antibody.

This BMPR1B antibody is available for research use only.

Antigen affinity

Human

O00238