NSJ Bioreagents

RICTOR Antibody

Product Code:
 
NSJ-F53372
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot the RICTOR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of RICTOR antibody at 1:2000 dilution + HepG2 lysate; Predicted molecular weight ~200 kDa.
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Western blot testing of RICTOR antibody at 1:2000 dilution + HepG2 lysate; Predicted molecular weight ~200 kDa.

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CodeSizePrice
NSJ-F53372-0.08ML0.08 ml£260.00
Quantity:
NSJ-F53372-0.4ML0.4 ml£502.00
Quantity:
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Further Information

Application Details :
Western blot: 1:2000
Application Note:
Titration of the RICTOR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
This RICTOR antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1068-1102 amino acids from the Central region of human RICTOR.
Limitation:
This RICTOR antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
Q6R327