ProSci

Adiponectin Recombinant Protein

Product Code:
 
PSI-40-614
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Insect
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Shipping:
 
blue ice or RT
Storage:
 
The lyophilized Adiponectin recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Adiponectin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Adiponectin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
 

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CodeSizePrice
PSI-40-614-0.005mg0.005mg£300.00
Quantity:
PSI-40-614-0.025mg0.025mg£428.00
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Further Information

Additional Names:
APN, Acdc, apM1, 30kDa, GBP28, adipo, Acrp30, Apm1, Adiponectin, 30 kDa adipocyte complement-related protein, ACRP30
Background:
Adiponectin is an adipose-derived secreted protein containing 236 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-β and class A scavenger receptor in macrophages). Recombinant Murine Adiponectin is a multimeric glycoprotein, which has a calculated molecular weight of 25.8 kDa and contains amino acids Val-21 to Asn-247 of the adiponectin precursor protein fused to an N-terminal histidine tag. As a result of glycosylation, Recombinant Murine Adiponectin migrates with an apparent molecular mass of approximately 31-36 kDa by SDS-PAGE gel, under reducing conditions.
Biological Activity:
Determined by a cytotoxic assay using M1 cells. The ED50 for this effect is 4.0-6.0 μg/mL.
NCBI Gene ID #:
11450
NCBI Official Name:
adiponectin, C1Q and collagen domain containing
NCBI Official Symbol:
Adipoq
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_033735.3
Protein GI Number:
87252711
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
High-5 Insect cells
Swissprot #:
Q60994

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