ProSci

VEGF R2 / KDR Recombinant Protein

Product Code:
 
PSI-11-519
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-519-0.1mg0.1mg£657.00
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Further Information

Additional Names:
KDR,CD309,FLK1,VEGFR,VEGFR2
Application Note:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 110.1 kDa. The protein migrates as 120-135 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Background References:
  • Holmes K,et al., 2007, Cell Signal. 19 (10): 2003?2012.
  • Stuttfeld E, et al., 2009, IUBMB Life 61 (9): 915?22.
  • Fujita, N, et al., 2008, Biochemical and biophysical research communications 372 (2): 367?372.
Buffer:
50 mM Tris, 100 mM Glycine, pH7.5
Fusion Tag:
Mouse IgG Fc Tag
NCBI Gene ID #:
16542
NCBI Official Name:
kinase insert domain protein receptor
NCBI Official Symbol:
Kdr
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
110.1 kDa
Protein Accession #:
NP 034742.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P35918

Documents