ProSci

LRP-6 (20-630) Recombinant Protein

Product Code:
 
PSI-11-297
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-297-0.1mg0.1mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
LRP-6,LRP6
Application Note:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 95.8 kDa. The protein migrates as 55 kDa and 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.
Background References:
  • Williams BO, et al. 2009. J Bone Miner Res. 24(2):171-8.
  • Li X, et al. 2005. J Biol Chem. 280(20):19883-7.
  • Zeng X, et al. 2005. Nature. 438(7069):873-7.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Mouse IgG Fc Tag
NCBI Gene ID #:
4040
NCBI Official Name:
LDLreceptorrelatedprotein6
NCBI Official Symbol:
LRP6
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
95.8 kDa
Protein Accession #:
NP_002327.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O75581

Documents