ProSci

MIS RII Recombinant Protein

Product Code:
 
PSI-11-295
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-295-0.1mg0.1mg£729.00
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Further Information

Additional Names:
MIS RII,MRII,AMHR2,AMHR,MISR2,AMH type II receptor
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.0 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
MIS RII (Mullerian inhibiting substance type II receptor), also known as AMHRII (anti-Mullerian hormone type II receptor), is a serine/threonine receptor with a single transmembrane domain that belongs to the family of type II receptors of the TGF-beta superfamily. Mutations in MIS RII result in persistent Mullerian duct syndrome (PMDS), persistent M?llerian duct syndrome (PMDS) is a sex-limited disorder in which males develop portions of the female reproductive tract. Anti-M?llerian hormone (AMH) and its receptor (AMHR2) induce the regression of the M?llerian ducts in male embryos, but the mechanism by which the Amhr2 gene is specifically activated is not fully understood.
Background References:
  • Qin C, et al. Reprod Biomed Online. 2014. 29(3):311-8.
  • Smit MM, et al. Reprod Domest Anim. 2018. 53(2):371-376.
  • Kimura AP, et al. Endocrinology. 2017. 158(11):4105-4121.
Buffer:
PBS, pH7.4
Fusion Tag:
Fc Tag
NCBI Gene ID #:
269
NCBI Official Name:
anti-Mullerianhormonereceptortype2
NCBI Official Symbol:
AMHR2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
40.0 kDa
Protein Accession #:
NP_065434.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q16671

Documents