ProSci

Plamotamab (CD3E/MS4A1) Antibody, Monoclonal

Product Code:
 
PSI-10-952
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Antibody Isotype:
 
IgG1-kappa / scFv-h-CH2-CH3
Antibody Clonality:
 
Recombinant Antibody
Regulatory Status:
 
RUO
Shipping:
 
blue ice
Storage:
 
Store at -80˚C
 

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CodeSizePrice
PSI-10-952-0.1mg0.1mg£657.00
Quantity:
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This product comes from: United States.
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Further Information

Additional Names:
XmAb-13676
Background:
Plamotamab (XmAb13676) is a tumor-targeted antibody that contains both a CD20 binding domain and a cytotoxic T-cell binding domain (CD3).An XmAb Bispecific Fc domain serves as the scaffold for these two antigen binding domains and confers long circulating half-life,stability and ease of manufacture on plamotamab.CD20 is highly expressed on B-cell tumor cells, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) cells.Engagement of CD3 by plamotamab activates T cells for highly potent and targeted killing of CD20-expressing tumor cells. The structural stability and modularity enabled by the XmAb Bispecific Fc domain allowed the tuning of plamotamab?s potency to balance anti-tumor activity with the reduction of immune toxicity that can result from T-cell activation.
Buffer:
PBS buffer pH7.5
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Chimeric,Humanized / CD3E/MS4A1 [Homo sapiens]
NCBI Organism:
homo sapiens
Purification:
>95%
Research Area:
Drug Analogues
Source:
CHO cells
User NOte:
Optimal dilutions for each application to be determined by the researcher.