ProSci

Ritonavir

Product Code:
 
PSI-10-040
Product Group:
 
Inhibitors and Activators
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
blue ice
Storage:
 
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
 

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PSI-10-040-50mg50mg£348.00
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Further Information

Additional Names:
RTV; A-84538; ABT-538; Abbot 84538; NSC 693184
Background:
HIV-1 and HIV-2 protease inhibitor. Glucose transporter 1 (GLUT1) and 4 (GLUT4) inhibitor. Inhibits transport of glucose across the plasma membranes of mammalian cells and consequently decreases glycolysis. Useful agent for immunometabolism research. Antitumor agent. Apoptosis inducer and cell proliferation inhibitor in GLUT1/GLUT4 overexpressed cancer cell lines. Tumor cells rely on elevated glucose consumption and metabolism for survival and proliferation. Glucose transporters mediating glucose entry are key proximal rate-limiting checkpoints. Among the fourteen SLC2A family members, GLUTs 1 and 4 are high-affinity glucose transporters. The proteinase inhibitor Kaletra, which is a mixture of the HIV-1 proteinase inhibitors lopinavir and ritonavir has been shown to be effective against SARS-CoV and MERS-CoV. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the coronavirus endopeptidase C30 (CEP_C30) of SARS-CoV-2. An initial randomized trial study was not successful.
CAS:
155213-67-5
Formula:
C37H48N6O5S2
InChi Key:
NCDNCNXCDXHOMX-XGKFQTDJSA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
720.9
Purity:
greater than or equal to 98% (HPLC)
Rtecs:
XA5310000
Smiles:
CC(C1=NC(CN(C(N[C@H](C(N[C@H](C[C@@H]([C@@H](NC(OCC2=CN=CS2)=O)CC3=CC=CC=C3)O)CC4=CC=CC=C4)=O)C(C)C)=O)C)=CS1)C
Solubility:
Soluble in DMSO (20mg/ml) or DMF (20mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (20mg/ml) or DMF (20mg/ml).

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