ProSci

Niclosamide

Product Code:
 
PSI-10-033
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
blue ice
Storage:
 
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry.Protect from moisture and oxygen Use/Stability:Stable for at least 2 years after receipt when stored at -20C.
 

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PSI-10-033-1g1g£336.00
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Further Information

Additional Names:
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; 2′5-Dichloro-4′-nitro-salicylanilide; BAY-2353; Bayluscid; Cestoid; HL2447; Yomesan
Background:
Antihelminthic, molluscicide and trypanocidal agent that inhibits mitochondrial oxidative phosphorylation and anaerobic ATP production. Anticancer agent with antiproliferative activity in a broad spectrum of cancer cells. Targets and inhibits multiple signaling pathways, including STAT3, NF-kB, Wnt/β-catenin, Notch and mTORC1. Shown to block TNF-α-induced IκBα phosphorylation, translocation of p65 and the expression of NF-κB-regulated genes and elevates reactive oxygen species (ROS) levels. Promotes Frizzled1 internalization, down-regulates the expression of Dishevelled-2 protein and inhibits β-catenin stabilization. Inhibits mTORC1 but not mTORC2 signaling in cells maintained in nutrient-rich conditions. Cell permeable selective STAT3 inhibitor (IC50=0.25μM). Inhibits the activation, nuclear translocation and transactivation of STAT3. Selective over STAT1, STAT5, JAK1, JAK2 and Src kinases. Induces cell cycle arrest, growth inhibition, autophagy and apoptosis. Inhibits S100A4 (Metastasin-1)-induced metastasis in vivo. Inhibits androgen receptor (AR) splice variants. Anti-inflammatory compound. Quorum sensing inhibitor. Broad-spectrum antiviral agent that targets acidified endosomes. Has been shown to inhibit replication of SARS and is a potential candidate to treat SARS-CoV-2 (COVID-19) infections. Antiobesity and antidiabetic agent. Positive allosteric neuropetide Y4 receptor ligand and increases energy expenditure and lipid metabolism through mitochondrial uncoupling.
CAS:
50-65-7
Formula:
C13H8Cl2N2O4
InChi Key:
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Merck Index:
5.110416667
Physical State:
Lyophilized
Predicted Molecular Weight:
327.1
Purity:
greater than or equal to 95%
Rtecs:
VN8400000
Smiles:
OC1=CC=C(Cl)C=C1C(NC2=CC=C([N+]([O-])=O)C=C2Cl)=O
Solubility:
Soluble in DMSO (30mg/ml), dimethylformamide or 100% ethanol. Sparingly soluble in water
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (30mg/ml), dimethylformamide or 100% ethanol. Sparingly soluble in water

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