ACE2 (human) (rec.) (His)

Chimerigen
Product Code: CHI-B232008
Product Group: Recombinant Proteins
Supplier: Chimerigen

CodeSizePrice
CHI-B232008-C100100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO

Further Information

Alternate Names/Synonyms:
SARS Receptor; Angiotensin-converting Enzyme 2; ACEH; Metalloprotease MPROT15; SARS-CoV-2 Receptor
Biological Activity:
Binds to the Spike protein of the coronavirus SARS-CoV-2.
Concentration:
1mg/ml after reconstitution
EClass:
32160000
Endotoxin:
<0.001EU/µg purified protein (LAL test).
Form (Short):
solid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Long Description:
Recombinant Proteins. Extracellular domain of human ACE2 (aa 1-740) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Lyophilized. Contains PBS. Endotoxin levels: <0.001EU/µg purified protein (LAL test).. Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19. It has been shown that human recombinant soluble ACE2 can significantly block early stages of SARS-CoV-2 infections.
NCBI, Uniprot Number:
Q9BYF1
Package Type:
Plastic Vial
Product Description:
Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19. It has been shown that human recombinant soluble ACE2 can significantly block early stages of SARS-CoV-2 infections.
Purity:
>90% (SDS-PAGE)
Sequence:
Extracellular domain of human ACE2 (aa 1-740) is fused at the C-terminus to a His-tag.
Source / Host:
HEK 293 cells
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.