South Bay Bio

K29-linked Tetra-Ubiqutin (human) (rec.) (untagged)

Product Code:
 
SBB-UP0078
Product Group:
 
Recombinant Proteins
Supplier:
 
South Bay Bio
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Dry Ice
Storage:
 
-80°C
 

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SBB-UP0078-C02525 ug£275.00
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This product comes from: Switzerland.
Typical lead time: 10-14 working days.
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Further Information

Alternate Names/Synonyms:
Ub4
Concentration:
Lot dependent.
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In 50mM HEPES pH 7.5.
Handling Advice:
Aliquot to avoid freeze/thaw cycles.
Long Description:
Recombinant Protein. Two enzymatically conjugated human ubiquitin (aa1-76) covalently linked through an isopeptide bond at K29 residue of one ubiquitin molecule and the C-terminal glycine residue of another ubiquitin molecule and untagged. Source/Host: E. coli. Liquid. In 50mM HEPES pH 7.5. The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural diversity of differently linked ubiquitin chains. In a ubiquitin chain, ubiquitin moieties can be conjugated through one of their lysine residues (K6, K11, K27, K29, K33, K48 and K63) or the N-terminal methionine residue (M1), offering countless possibilities to assemble a specific polymer. Ubiquitin molecules can also be modified by other post-translational modifications, including acetylation and phosphorylation, adding another layer of ubiquitin signal regulation and diversification. K29-linked polyubiquitination has been shown to be an inhibitor of Wnt signaling, which plays an important role in embryogenesis, and its deregulation has been shown to play a role in tumorigenesis. This protein is formed with wild-type human recombinant ubiquitin and linkage-specific enzymes. Ideal for investigating ubiquitin-binding proteins and as substrates for ubiquitin-specific isopeptidases. Reaction conditions will need to be optimized for each specific application.
Molecular Weight:
~34kDa
NCBI, Uniprot Number:
P0CG47
Package Type:
Plastic Vial
Product Description:
The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural diversity of differently linked ubiquitin chains. In a ubiquitin chain, ubiquitin moieties can be conjugated through one of their lysine residues (K6, K11, K27, K29, K33, K48 and K63) or the N-terminal methionine residue (M1), offering countless possibilities to assemble a specific polymer. Ubiquitin molecules can also be modified by other post-translational modifications, including acetylation and phosphorylation, adding another layer of ubiquitin signal regulation and diversification. K29-linked polyubiquitination has been shown to be an inhibitor of Wnt signaling, which plays an important role in embryogenesis, and its deregulation has been shown to play a role in tumorigenesis. This protein is formed with wild-type human recombinant ubiquitin and linkage-specific enzymes. Ideal for investigating ubiquitin-binding proteins and as substrates for ubiquitin-specific isopeptidases. Reaction conditions will need to be optimized for each specific application.
Purity:
>95% (SDS-PAGE)
Sequence:
Two enzymatically conjugated human ubiquitin (aa1-76) (Accession Nr. P0CG47 http://www.ncbi.nlm.nih.gov/protein/P0CG47 ) covalently linked through an isopeptide bond at K29 residue of one ubiquitin molecule and the C-terminal glycine residue of another ubiquitin molecule and untagged.
Source / Host:
E. coli
TAGs:
no TAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -80°C.