ProSci

HB-EGF Recombinant Protein

Product Code:
 
PSI-40-630
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or room temp
Storage:
 
The recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
 

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PSI-40-630-10ug10ug£307.00
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This product comes from: United States.
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Further Information

Additional Names:
Heparin Binding EGF-like growth factor, HBEGF, Diphtheria toxin receptor (DTR)
Background:
HB-EGF is an EGF-related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells, and vascular SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant Human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extracellular EGF-like and heparin-binding domains of the full length HB-EGF protein.
Biological Activity:
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is < 1.0 ng/ml, corresponding to a specific activity of ? 1 x 106 units/mg.
NCBI Gene ID #:
1839
NCBI Official Name:
heparin binding EGF like growth factor
NCBI Official Symbol:
HBEGF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Purity:
> 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q99075

Documents