ProSci

TIGIT Detection Set

Product Code:
 
PSI-SD8800
Product Group:
 
Antibody Detection Sets
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
Dry Ice
Storage:
 
TIGIT antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 

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PSI-SD8800-1Set1Set£488.00
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This product comes from: United States.
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  • Further Information
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Further Information

Background:
TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).
Background References:
  • Stanietsky N, Simic H, Arapovic J, et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 2009; 106:17858-63.
  • Johnston RJ, Comps-Agrar L, Hackney J, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell 2014; 26:923-37.
Buffer:
TIGIT Antibodies are supplied in PBS.
Concentration:
Antibody 1 mg/mL
Conjugate:
Unconjugated
Immunogen:
TIGIT antibodies were raised against a recombinant protein corresponding to amino acids 22-141 of human TIGIT.
Physical State:
Liquid
Purification:
TIGIT Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein.??They also contains a myc-tag for detection.
Set Contents:
20 μg:
TIGIT Antibody [2B5], Cat. No. SD8824
TIGIT Antibody [2F7], Cat. No. SD8827
TIGIT Antibody [2C6], Cat. No. SD8828
TIGIT Antibody [2C7], Cat. No. SD8829
TIGIT Antibody [2D7], Cat. No. SD8830

100 μg:
cMyc-tag Antibody [5G5H7], Cat. No. PM-7669
User Note:
Optimal dilutions for each application to be determined by the researcher.

Documents

References

  1. Stanietsky N, Simic H, Arapovic J, et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 2009; 106:17858-63.
  2. Johnston RJ, Comps-Agrar L, Hackney J, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell 2014; 26:923-37.