Further Information
PDE6A, Alpha-PDE, CGMP phosphodiesterase alpha, CGPR-A, PDE6alpha, PDE V-B1, PDEA, Phosphodiesterase 6a, RP43, GMP-PDE alpha
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 656-860 of human PDE6A (NP_000431.2).
5145
phosphodiesterase 6A, cGMP-specific, rod, alpha
PDE6A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 120kDa
Affinity purification
Neuroscience, Signal Transduction
P16499
Optimal dilutions for each application to be determined by the researcher.