Further Information
CSNB3, CSNBAD2, GMP-PDEbeta, PDEB, RP4rd1, rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta, GMP-PDE beta, phosphodiesterase 6B, cGMP-specific, rod, beta, rod cGMP-phosphodiesterase beta-subunit
WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
IF: 1:50 - 1:100
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PDE6B (NP_001138763.1).
5158
phosphodiesterase 6B
PDE6B
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 98kDa
Affinity purification
Neuroscience, Signal Transduction
P35913
Optimal dilutions for each application to be determined by the researcher.