Further Information
GAD1, SCP, OTTHUMP00000204995, OTTHUMP00000204994, OTTHUMP00000204993, OTTHUMP00000204990, glutamate decarboxylase 67 kDa isoform, glutamate decarboxylase 1 (brain, 67kDa), glutamate decarboxylase 1, GAD-67, GAD, FLJ45882, 67 kDa glutamic acid decarboxylase, GAD67
WB: 1:500 - 1:2000
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GAD1 (NP_000808.2).
2571
glutamate decarboxylase 1 (brain, 67kDa)
GAD1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 67kDa
Affinity purification
Immunology, Neuroscience, Signal Transduction
Q99259
Optimal dilutions for each application to be determined by the researcher.