Antibody Clonality:
Polyclonal
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
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United States.
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Further Information
ADAMTS4, ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688
WB: 1:500 - 1:2000
IF: 1:50 - 1:200
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 52-315 of human ADAMTS4 (NP_005090.3).
9507
ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 80kDa
Affinity purification
Cancer, Cell Cycle, Signal Transduction
O75173
Optimal dilutions for each application to be determined by the researcher.