Further Information
NR1I3, CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
WB: 1:500 - 1:2000
IF: 1:50 - 1:200
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human NR1I3 (NP_001070948.1).
9970
nuclear receptor subfamily 1, group I, member 3
NR1I3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 45kDa
Affinity purification
Cancer, Signal Transduction, Transcription
Q14994
Optimal dilutions for each application to be determined by the researcher.