Further Information
COL4A3, collagen, type IV, alpha 3 (Goodpasture antigen), collagen IV, alpha-3 polypeptide, collagen alpha-3(IV) chain, tumstatin
WB: 1:500 - 1:2000
IF: 1:50 - 1:200
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
A synthetic peptide corresponding to a sequence within amino acids 1600 to the C-terminus of human COL4A3 (NP_000082.2).
1285
collagen, type IV, alpha 3
COL4A3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 162kDa
Affinity purification
Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction
Q01955
Optimal dilutions for each application to be determined by the researcher.
