ProSci

PTPRN2 Antibody

Product Code:
 
PSI-15-722
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or RT
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
1 / 5
Western blot analysis of extracts of various cell lines, using PTPRN2 antibody (15-722) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 5s.
2 / 5
Immunohistochemistry of paraffin-embedded human mammary cancer using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens).
3 / 5
Immunohistochemistry of paraffin-embedded human colon carcinoma using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens).
4 / 5
Immunohistochemistry of paraffin-embedded human lung cancer using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens).
5 / 5
Immunohistochemistry of paraffin-embedded mouse pancreas using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens).
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Western blot analysis of extracts of various cell lines, using PTPRN2 antibody (15-722) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 5s.
Immunohistochemistry of paraffin-embedded human mammary cancer using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human colon carcinoma using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse pancreas using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens).

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PSI-15-722-50uL50uL£433.00
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Further Information

Additional Names:
Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387
Application Note:
WB: 1:500 - 1:2000

IHC: 1:50 - 1:100

IF: 1:50 - 1:100
Background:
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human PTPRN2 (NP_570858.2).
NCBI Gene ID #:
5799
NCBI Official Name:
Receptor-type tyrosine-protein phosphatase N2
NCBI Official Symbol:
PTPRN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 111kDa
Purification:
Affinity purification
Research Area:
Immunology, Signal Transduction
Swissprot #:
Q92932
User NOte:
Optimal dilutions for each application to be determined by the researcher.