Further Information
SHP-1, protein tyrosine phosphatase, non-receptor type 6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, 70 kDa SHP-1L protein, hematopoietic cell phosphatase, hematopoietic cell protein-tyrosine phosphatase, protein-tyrosine phosphatase 1C, PTP1C
WB: 1:500 - 1:2000
IF: 1:50 - 1:200
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human PTPN6 (NP_002822.2).
5777
protein tyrosine phosphatase, non-receptor type 6
PTPN6
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 68kDa
Affinity purification
Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction
P29350
Optimal dilutions for each application to be determined by the researcher.