Further Information
ATR, FRAP-related protein-1, FCTCS, SCKL1, MEC1, Protein kinase ATR, Rad3 related protein, SCKL, FRAP-related protein 1, FRP1
WB: 1:500 - 1:2000
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human ATR (NP_001175.2).
545
ataxia telangiectasia and Rad3 related
ATR
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 316kDa
Affinity purification
Apoptosis, Cancer, Cell Cycle, Signal Transduction
Q13535
Optimal dilutions for each application to be determined by the researcher.