Further Information
ALDH2, nucleus-encoded mitochondrial aldehyde dehydrogenase 2, mitochondrial aldehyde dehydrogenase 2, MGC1806, liver mitochondrial ALDH, ALDM, ALDHI, ALDH-E2, ALDH class 2, aldehyde dehydrogenase 2 family (mitochondrial), acetaldehyde dehydrogenase 2
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human ALDH2 (NP_000681.2).
217
aldehyde dehydrogenase 2 family (mitochondrial)
ALDH2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 54kDa
Affinity purification
Cancer, Signal Transduction
P05091
Optimal dilutions for each application to be determined by the researcher.