ProSci

MMP7 Antibody

Product Code:
 
PSI-13-253
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or RT
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
1 / 3
Western blot analysis of extracts of HT-29 cells, using MMP7 antibody (13-253) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 15s.
2 / 3
Immunohistochemistry of paraffin-embedded human colon carcinoma using MMP7 antibody (13-253) at dilution of 1:100 (40x lens).
3 / 3
Immunohistochemistry of paraffin-embedded human gastric cancer using MMP7 antibody (13-253) at dilution of 1:100 (40x lens).
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Western blot analysis of extracts of HT-29 cells, using MMP7 antibody (13-253) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 15s.
Immunohistochemistry of paraffin-embedded human colon carcinoma using MMP7 antibody (13-253) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human gastric cancer using MMP7 antibody (13-253) at dilution of 1:100 (40x lens).

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PSI-13-253-50uL50uL£433.00
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Further Information

Additional Names:
MMP7, MMP-7, MPSL1, PUMP-1
Application Note:
WB: 1:500 - 1:2000

IHC: 1:50 - 1:200
Background:
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-267 of human MMP7 (NP_002414.1).
NCBI Gene ID #:
4316
NCBI Official Name:
matrix metallopeptidase 7 (matrilysin, uterine)
NCBI Official Symbol:
MMP7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 26kDa
Purification:
Affinity purification
Research Area:
Cancer, Cell Cycle, Signal Transduction
Swissprot #:
P09237
User NOte:
Optimal dilutions for each application to be determined by the researcher.