ANGPTL3 (fibrinogen-like domain) (human) (rec.)
| Code | Size | Price |
|---|
| AG-40A-0071Y-C010 | 10 ug | £220.00 |
Quantity:
| AG-40A-0071Y-C050 | 50 ug | £610.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Angiopoietin-like Protein 3; Angiopoietin-5; ANG-5
Concentration:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Long Description:
Recombinant Protein. Fibrinogen-like domain of human ANGPTL3 (aa 224-460) is fused at the N-terminus to a FLAG®-tag. Source/Host: HEK 293 cells. Endotoxin: <0.01EU/µg purified protein (LAL test). Lyophilized. Contains PBS. ANGPTL3 (Angiopoietin-like protein 3) regulates angiogenesis and also directly regulates lipid, glucose and energy metabolism. Angiopoietin-like 3 (ANGPTL3) is a regulator of plasma triglyceride (TRG) levels due to its inhibitory action on the activity of lipoprotein lipase (LPL). ANGPTL3 induces angiogenesis by binding to integrin alphavbeta3. ANGPTL3 is predominantly produced in the liver and can therefore be classified as a hepatokine. In the human plasma, ANGPTL3 is cleaved to released two fragments: a N-terminal coiled-coil domain-containing fragment (aa17-207) important for inhibiting the lipolysis of triglyceride and the C-terminal fibrinogen-like domain-containing fragment (aa208-460).
Molecular Weight:
~35-38kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q9Y5C1
Package Type:
Plastic Vial
Product Description:
ANGPTL3 (Angiopoietin-like protein 3) regulates angiogenesis and also directly regulates lipid, glucose and energy metabolism. Angiopoietin-like 3 (ANGPTL3) is a regulator of plasma triglyceride (TRG) levels due to its inhibitory action on the activity of lipoprotein lipase (LPL). ANGPTL3 induces angiogenesis by binding to integrin alphavbeta3. ANGPTL3 is predominantly produced in the liver and can therefore be classified as a hepatokine. In the human plasma, ANGPTL3 is cleaved to release two fragments: a N-terminal coiled-coil domain-containing fragment (aa17-207) important for inhibiting the lipolysis of triglyceride and the C-terminal fibrinogen-like domain-containing fragment (aa208-460).
Purity:
>95% (SDS-PAGE)
Sequence:
Fibrinogen-like domain of human ANGPTL3 (aa 224-460) is fused at the N-terminus to a FLAG®-tag.
Source / Host:
HEK 293 cells
TAGs:
FLAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors: H.E. Broxmeyer, et al.; Blood Cells Mol. Dis. 48, 25 (2012)