Sheep anti Human p53

Applications: Western Blot (1-10 ug/ml, Immunoprecipitation, staining of formalin-fixed and paraffinembedded tissue).

GST p53 fusion protein containing amino acids 1-393 of human p53was used as immunogen. p53 has a molecular weight of 53kDa p53 is a transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Cell Cycle

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Western Blotting

GST p53 fusion protein containing amino acids 1-393 of human p53

Unconjugated

Products are stable for one year from purchase when stored properly

Ammonium Sulfate Precipitation

Sheep were immunized with a GST-p53 fusion protein containing amino acids 1-393 of human p53

Sheep anti human p53, hp53

P04637